https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40357 Wed 27 Jul 2022 15:15:01 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54898 Wed 20 Mar 2024 13:32:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46724 Tue 29 Nov 2022 11:27:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43899 850K CpGs. We regressed CpGs on eCO and tested via mediation analysis whether CpGs link eCO to birth weight. Nine smoking related CpG sites were significantly associated with birth weight. Among these nine CpGs the methylation of cg02264407 on the LMO7 gene was statistically significant and linked with eCO measurements. eCO greater than six ppm showed a 2.3% decrease in infant DNAm (p = 0.035) on the LMO7 gene. A 1% decrease in methylation at this site resulted in decreased birth weight by 44.8 g (p = 0.003). None of the nine CpGs tested was associated with self-reported smoking. This is the first study to report potential mediation of DNA methylation, linking eCO measurements during early pregnancy with birth weight.]]> Tue 04 Oct 2022 13:59:31 AEDT ]]>